| ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 1
| Issue : 1 | Page : 21-24 |
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Combined scraping, coagulation, and subconjunctival bevacizumab in corneal transplantation for bullous keratopathy with corneal neovascularization
Chun-Chi Chiang, Jane-Ming Lin, Yi-Yu Tsai
Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
Correspondence Address:
Yi-Yu Tsai
Department of Ophthalmology, China Medical University Hospital, No. 2 Yue-Der Road, Taichung
Taiwan
 Source of Support: None, Conflict of Interest: None  | 1 |
DOI: 10.1016/j.tjo.2011.08.004
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Purpose: This study investigated clinical outcomes of the combined method of scraping, coagulation, and subconjunctival bevacizumab for the treatment of corneal neovascularization (NV) in penetrating keratoplasty (PKP).
Methods: This study included patients undergoing PKP who were diagnosed with bullous keratopathy with dense subepithelial scarring that was not suitable for Descemet’s stripping automated endothelial keratoplasty. Corneal NV was treated by scraping the corneal epithelium and lightly coagulating the superficial corneal stromal NV combined with subconjunctival bevacizumab injection at the end of surgery. Patients without corneal NV were used as the control group.
Results: There were six patients with vascularized corneas in the study group and three patients without vascularized corneas in the control group. The original corneal NV in the study group disappeared in all patients after surgery. Three of the six (50%) study patients experienced recurrent corneal NV. One of the three (33%) control patients developed corneal NV. These patients had no corneal NV recurrences over the next 6 months after repeat treatment. In both groups, no graft failure or chronic epithelial defects occurred.
Conclusion: The combination of scraping the corneal epithelium, coagulating the superficial corneal stromal NV and the feeding vessels in the sclera after peritomy, and subconjunctival bevacizumab injection is an effective method to treat corneal NV in corneal transplantation for bullous keratopathy.
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