• Users Online: 1421
  • Print this page
  • Email this page
Year : 2014  |  Volume : 4  |  Issue : 3  |  Page : 120-122

Effects of ranibizumab on human corneal endothelial cells

Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan

Correspondence Address:
Chun-Chi Chiang
Department of Ophthalmology, China Medical University Hospital, Number 2, Yue-Der Road, Taichung 404
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.tjo.2014.04.004

Rights and Permissions

Purpose: This study aims to evaluate corneal endothelial changes occurring over a 3-month period after intravitreal injections of ranibizumab in patients with wet age-related macular degeneration. Methods: This is a prospective case series. A total of 29 patients (29 eyes) received a 0.5-mg intravitreal injection of ranibizumab. Specular microscopy, including measurement of central corneal thickness and endothelial cell count, was performed on each patient prior to and after completing three intravitreal injections. Results: All patients received three intravitreal injections and were followed up for a mean of 3 months. There was no significant change in corneal thickness (p = 0.32) or endothelial cell density (p = 0.38) after ranibizumab injections. Conclusion: Intravitreal ranibizumab injections (0.5 mg) have no harmful effects on corneal endothelial cells.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded106    
    Comments [Add]    
    Cited by others 1    

Recommend this journal