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ORIGINAL ARTICLE
Year : 2014  |  Volume : 4  |  Issue : 3  |  Page : 120-122

Effects of ranibizumab on human corneal endothelial cells


Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan

Correspondence Address:
Chun-Chi Chiang
Department of Ophthalmology, China Medical University Hospital, Number 2, Yue-Der Road, Taichung 404
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.tjo.2014.04.004

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Purpose: This study aims to evaluate corneal endothelial changes occurring over a 3-month period after intravitreal injections of ranibizumab in patients with wet age-related macular degeneration. Methods: This is a prospective case series. A total of 29 patients (29 eyes) received a 0.5-mg intravitreal injection of ranibizumab. Specular microscopy, including measurement of central corneal thickness and endothelial cell count, was performed on each patient prior to and after completing three intravitreal injections. Results: All patients received three intravitreal injections and were followed up for a mean of 3 months. There was no significant change in corneal thickness (p = 0.32) or endothelial cell density (p = 0.38) after ranibizumab injections. Conclusion: Intravitreal ranibizumab injections (0.5 mg) have no harmful effects on corneal endothelial cells.


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