| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 4
| Issue : 3 | Page : 120-122 |
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Effects of ranibizumab on human corneal endothelial cells
Yi-Jung Ho, Yi-Yu Tsai, Jane-Ming Lin, Wen-Lu Chen, Chun-Ju Lin, Chun-Chi Chiang
Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
Correspondence Address:
Chun-Chi Chiang
Department of Ophthalmology, China Medical University Hospital, Number 2, Yue-Der Road, Taichung 404
Taiwan
 Source of Support: None, Conflict of Interest: None  | 2 |
DOI: 10.1016/j.tjo.2014.04.004
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Purpose: This study aims to evaluate corneal endothelial changes occurring over a 3-month period after intravitreal injections of ranibizumab in patients with wet age-related macular degeneration.
Methods: This is a prospective case series. A total of 29 patients (29 eyes) received a 0.5-mg intravitreal injection of ranibizumab. Specular microscopy, including measurement of central corneal thickness and endothelial cell count, was performed on each patient prior to and after completing three intravitreal injections.
Results: All patients received three intravitreal injections and were followed up for a mean of 3 months. There was no significant change in corneal thickness (p = 0.32) or endothelial cell density (p = 0.38) after ranibizumab injections.
Conclusion: Intravitreal ranibizumab injections (0.5 mg) have no harmful effects on corneal endothelial cells.
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