Advanced Search
  • Users Online: 170
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 3  |  Page : 153-166

Ocular manifestation, comorbidities, and detection of severe acute respiratory syndrome-coronavirus 2 from conjunctiva in coronavirus disease 2019: A systematic review and meta-analysis

Xiao Chun Ling1, Eugene Yu-Chuan Kang1, Jui-Yen Lin1, Hung-Chi Chen2, Chi-Chun Lai3, David Hui-Kang Ma4, Wei-Chi Wu2
1 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan
2 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan
3 Department of Medicine, College of Medicine, Chang Gung University, Taoyuan; Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan
4 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou; Department of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Ophthalmology, Xiamen Chang Gung Hospital, Xiamen, Fujian, China

Correspondence Address:
Dr. David Hui-Kang Ma
Department of Ophthalmology, Chang Gung Memorial Hospital, No. 5, FuHsin Road, Taoyuan 333

Dr. Wei-Chi Wu
Department of Ophthalmology, Chang Gung Memorial Hospital, No. 5, FuHsin Road, Taoyuan 333
Taiwan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tjo.tjo_53_20

Rights and Permissions

The coronavirus disease 2019 (COVID 19) pandemic has presented major challenges to ophthalmologists. Reports have shown that ocular manifestations can be the first presenting symptoms of COVID 19 infection and conjunctiva may be a portal of entry for the severe acute respiratory syndrome (SARS) associated coronavirus 2 (SARS CoV 2). The purpose of this article is to provide general guidance for ophthalmologists to understand the prevalence of ocular presentation in COVID 19 patients and to reduce the risk of transmission during practice. Relevant studies published in the period of November 1, 2019, and July 15, 2020, regarding ocular manifestations of COVID 19 and detection of SARS CoV 2 in the eye were included in this systematic review and meta analysis. The pooled prevalence of the ocular manifestations has been estimated at 7% (95% confidence interval [CI]: 0.03–0.10) among COVID 19 patients. The pooled detection rate of SARS CoV 2 from conjunctiva was low (1%, 95% CI: 0.00–0.03). Conjunctival symptoms were the most common ocular manifestations in COVID 19, but the positive detection rate of the SARS CoV 2 virus by reverse transcription–polymerase chain reaction of conjunctival tears or secretions remained low. No study has shown a definite transmission of COVID 19 through ocular mucosa or secretions. In summary, ocular manifestations in COVID 19 patients commonly comprise ocular surface symptoms. Although a low prevalence of ocular symptoms was encountered among patients infected by SARS CoV 2, it is imperative for all ophthalmologists to understand the full spectrum of COVID 19 symptoms or signs including those of the eyes as well as to adopt appropriate protective measures during clinical practice.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed6343    
    Printed136    
    Emailed0    
    PDF Downloaded783    
    Comments [Add]    
    Cited by others 12    

Recommend this journal

 

© Taiwan Journal of Ophthalmology | Published by Wolters Kluwer - Medknow
Online since 10th Mar, 2017