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Year : 2022  |  Volume : 12  |  Issue : 2  |  Page : 138-146

Subretinal drusenoid deposits: An update

1 Department of Ophthalmology, Hospital México, San José, Costa Rica
2 Asociados de Macula, Vitreo y Retina de Costa Rica, San José, Costa Rica
3 Asociados de Macula, Vitreo y Retina de Costa Rica, San José, Costa Rica; Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois College of Medicine, Chicago, IL, USA

Correspondence Address:
Dr. Lihteh Wu
Asociados de Macula, Vitreo y Retina de Costa Rica, Primer Piso Torre Mercedes Paseo Colón, San José

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.tjo_18_22

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A wide spectrum of phenotypic manifestations characterizes age-related macular degeneration (AMD). Drusen is considered the hallmark of AMD and is located underneath the retinal pigment epithelium (RPE). In contrast, subretinal drusenoid deposits (SDDs), also known as reticular pseudodrusens, are located in the subretinal space, on top of the RPE. SDDs are poorly detected by clinical examination and color fundus photography. Multimodal imaging is required for their proper diagnosis. SDDs are topographically and functionally related to rods. SDDs cause a deep impairment in retinal sensitivity and dark adaptation. SDDs are dynamic structures that may grow, fuse with each other, or regress over time. An intermediate step in some eyes is the development of an acquired vitelliform lesion. The presence of SDD confers an eye a high risk for the development of late AMD. SDD leads to macular neovascularization, particularly type 3, geographic atrophy, and outer retinal atrophy.

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