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CASE REPORT
Year : 2022  |  Volume : 12  |  Issue : 4  |  Page : 482-486

Intravitreal aflibercept combined with transpupillary thermotherapy in the treatment of refractory macular edema due to primary uveal melanoma


1 Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan
2 Department of Ophthalmology, China Medical University Hospital; School of Medicine, College of Medicine, China Medical University; Department of Optometry, Asia University, Taichung
3 Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan; Stanford University School of Medicine, Stanford, California, USA, Taiwan
4 Department of Ophthalmology, China Medical University Hospital; School of Medicine, College of Medicine, China Medical University; Department of Optometry, Asia University, Taichung, Taiwan

Correspondence Address:
Dr. Chun-Ju Lin
Department of Ophthalmology, 2 Yuh-Der Road, Taichung 40447

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tjo.tjo_44_21

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We reported a 74 year old Asian female with a uveal tumor with subretinal fluid (SRF) and cystoid macula edema. Since she declined biopsy, multimodal imaging study was performed, including fundus photography, ultrasonography, optical coherence tomography, fluorescein angiography, and magnetic resonance imaging. Uveal melanoma was diagnosed. However, despite aggressive treatment with TTT and three adjuvant intravitreal bevacizumab doses, SRF, and cystoid macula edema were persistent. Therefore, aflibercept was administered, resulting in anatomical and functional improvement within 1 month, which lasted for 12 months. Aflibercept offered great efficacy in improving refractory macular edema in this case of primary uveal melanoma. Multimodal imaging can provide us with more diagnostic clues in differentiating the nature of intraocular tumors.


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