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Year : 2023  |  Volume : 13  |  Issue : 1  |  Page : 55-61

Clinical outcomes of prestripped, prestained, and preloaded Descemet's membrane endothelial keratoplasty (”P3 DMEK”)

1 University of Michigan Medical School; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
2 Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan; Corneal Associates of New Jersey, Fairfield NJ, USA
3 Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA
4 University of Michigan Medical School, Ann Arbor, Michigan, USA

Correspondence Address:
Dr. Shahzad I Mian
1000 Wall Street, Ann Arbor, Michigan 48105
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.TJO-D-22-00155

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PURPOSE: Despite faster healing and reduced risk of rejection, some surgeons are hesitant to adopt Descemet membrane endothelial keratoplasty (DMEK) due to difficult intraoperative tissue preparation. Use of eye bank prestripped, prestained, and preloaded (p3) DMEK tissue can reduce the learning curve and risk of complications. MATERIALS AND METHODS: We conducted a prospective study including 167 eyes undergoing p3 DMEK and compared outcomes to a retrospective chart review of 201 eyes that underwent standard DMEK surgery. The primary outcomes were graft failure, detachment, and re-bubbling frequency. The secondary outcomes included baseline and postoperative visual acuity at months 1, 3, 6, and 12. Baseline and postoperative central corneal thickness (CCT) and endothelial cell counts (ECC) were collected. RESULTS: ECC decrease for p3 DMEK at 3, 6, and 12 months were 15.0%, 18.0%, and 21.0%, respectively. Forty (24%) of p3 DMEK and 72 (35.8%) of standard DMEK eyes had at least a partial graft detachment. There was no difference in CCT, graft failures, or re-bubble frequency. At 6 months, mean visual acuity was 20/26 and 20/24 for standard and p3 DMEK, respectively. Mean case time for p3 DMEK with phaco or p3 DMEK alone was 33 and 24 min, respectively. Mean case time for eyes undergoing DMEK with phaco or DMEK alone was 59 and 45 min, respectively. CONCLUSION: P3 DMEK tissue is safe and can provide excellent clinical outcomes that are comparable to standard DMEK tissue. Eyes undergoing p3 DMEK may have lower graft detachment and ECC loss.

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