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Peripheral ulcerative keratitis in a patient with granulomatous rosacea
Fang-Chi Hsiao1, Yaa-Jyuhn James Meir2, Ching-Hsi Hsiao3, Kuan-Jen Chen4, David Hui-Kang Ma5, Wei-Chi Wu4, Hung-Chi Chen6
1 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan
2 Department of Biomedical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan
3 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou; Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan
4 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou; Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan, Taiwan
5 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou; Department of Traditional Chinese Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan
6 Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou; Department of Medicine, Chang Gung University College of Medicine, Taoyuan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan
Correspondence Address:
Prof. Hung-Chi Chen
5 Fuxing Street, Guishan District, Taoyuan 333423
Taiwan
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/tjo.TJO-D-22-00079
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A 24-year-old woman visited our emergency department due to intermittent dull pain in the right eye, blurred vision, foreign body sensation for 3 weeks, and progressive facial rash with pustules for 3 months. She had a history of recurring skin rash on her face and extremities since early adolescence. Peripheral ulcerative keratitis (PUK) was diagnosed based on slit-lamp examination and corneal topography and then granulomatous rosacea (GR) based on clinical manifestations and skin pathology. Topical prednisolone, artificial tears, oral doxycycline, oral prednisolone, and topical clindamycin were administered. After 1 month, PUK progressed to corneal perforation probably due to eye rubbing. The corneal lesion was repaired with a glycerol-preserved corneal graft. A dermatologist prescribed oral isotretinoin for 2 months in conjunction with topical betamethasone gradually tapered for 14 months. After 34 months of follow-up, no signs of skin and ocular recurrence were noted, and the cornea graft was intact. In conclusion, PUK may present with GR, and oral isotretinoin may be an effective therapy for PUK in the setting of GR.
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