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ORIGINAL ARTICLE
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A study of effect of hemodialysis on macular thickness in patients with end-stage renal disease


1 Department of Vitreo-Retina, Sankara Eye Hospital, Shimoga, Karnataka, India
2 Department of Cornea and Refractive Services, Sankara Eye Hospital, Shimoga, Karnataka, India
3 Department of Pediatric Ophthalmology and Strabismus, Sankara Eye Hospital, Shimoga, Karnataka, India
4 Department of Cataract and Trauma, Sankara Eye Hospital, Shimoga, Karnataka, India

Correspondence Address:
Pradeep Sagar,
Department of Vitreo-Retina, Sankara Eye Hospital, Harakere, Thirthahalli Road, Shimoga - 577 202, Karnataka
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.tjo_86_20

PURPOSE: The purpose was to study the effect of hemodialysis (HD) on macular thickness in patients with diabetic retinopathy (DR) and end-stage renal disease. MATERIALS AND METHODS: In this prospective observational study, patients undergoing HD for diabetic nephropathy were recruited. None of the patients received treatment for DR per se during the study duration. Patients underwent ocular examination and optical coherence tomography before HD and were followed up on day 3 and day 30. At each visit, central subfield macular thickness (CSMT) and total macular volume (TMV) were measured and compared with baseline values using analysis of variance and post hoc test (Wilcoxon's matched-pairs signed-rank test). RESULTS: Thirty-one eyes of 19 patients were recruited in the study. The mean CSMT decreased from baseline value of 278.93 ± 45.01 µ to 239.81 ± 40.54 µ at the end of 30 days (P < 0.005). The mean TMV decreased from baseline value of 8.14 ± 0.68 mm3 to 7.80 ± 0.63 mm3 on day 30 (P < 0.005). CONCLUSION: There was a statistically significant reduction in CSMT and TMV after HD at 30 days as compared to baseline values. HD alone results in reduction of macular thickness over short term.


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