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The clinical presentation and treatment of an invasive conjunctival squamous spindle cell carcinoma


1 Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan; Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan
2 Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Taiwan
3 Department of Pathology, Chang Gung Memorial Hospital, Chiayi, Taiwan

Correspondence Address:
Jin-Jhe Wang,
No. 6, W. Sec., Chiapu Road, Puzih City, Chiayi County 61363
Taiwan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.tjo_26_21

Ocular surface squamous neoplasia represents neoplastic epithelial abnormalities of conjunctiva and cornea, ranging from squamous dysplasia to invasive squamous cell carcinoma and is both sight- and life-threatening. Squamous spindle cell carcinoma (SSCC) of conjunctiva is a rare variant with distinct behavior which is thought to be more locally aggressive. We describe an 83-year-old woman with a progressively enlarging huge SSCC in her right eye over the past 2 years. The tumor bulged out with local invasion into intraocular and orbital cavities. Wide excision of the tumor with frozen section control was performed. After surgery, topical 0.03% mitomycin C was given as adjuvant therapy. At 40-month follow-up, the lesion site showed no evidence of local recurrence. This case provides a valuable and complete experience of the clinical presentation for the progression and treatment of this rare disease.


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    -  Chen CY
    -  Wang SW
    -  Lai CH
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    -  Lin YY
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