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Latanoprost-associated cystoid macular edema in a patient with phakic eyes


1 Department of Ophthalmology, MacKay Memorial Hospital, Taipei City; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan
2 Department of Ophthalmology, MacKay Memorial Hospital, Taipei City, Taiwan
3 Department of Ophthalmology, MacKay Memorial Hospital, Taipei City; Department of Medicine, MacKay Medical College, New Taipei City; Department of Optometry, MacKay Junior College of Medicine, Nursing, and Management, Taipei City, Taiwan
4 Department of Ophthalmology, MacKay Memorial Hospital, Taipei City; Department of Medicine, MacKay Medical College, New Taipei City; MacKay Junior College of Medicine, Nursing, and Management, Taipei City, Taiwan

Correspondence Address:
Yu-Wen Lan,
No. 92, Sec. 2, Zhongshan N. Rd., Taipei City 10449
Taiwan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.tjo_19_22

Here, we report a case of bilateral cystoid macular edema (CME) in a woman with phakic eyes after 22 years of latanoprost use. Optical coherence tomography revealed multiple intraretinal cysts, and fluorescein angiography revealed characteristic petaloid dye leakage from the perifoveal capillaries. A cause-effect relationship was suspected when CME resolved after switching from latanoprost to dorzolamide, as confirmed by positive rechallenge and dechallenge tests. Since prostaglandin analog-induced CME has only been reported in patients with pseudophakic, aphakic, or phakic eyes with retinal conditions predisposing to macular edema, this seems to be the first reported case of latanoprost-induced CME in a patient with phakic eyes without retinal risk factors.


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