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Unilateral acute idiopathic maculopathy related to hand–foot–mouth disease: Case report and literature review

1 Department of Ophthalmology, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan
2 Department of Ophthalmology, Taipei City Hospital, Ren-Ai Branch; Department of Ophthalmology, Taipei City Hospital, Zhongxiao Branch; Department of Ophthalmology, National Taiwan University Hospital; Department of Special Education, University of Taipei; Department of Medicine, Mackay Medical College, Taipei, Taiwan

Correspondence Address:
I-Mo Fang,
No. 87 Tonde Road, Nankang District, Taipei
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.TJO-D-22-00139

Unilateral acute idiopathic maculopathy (UAIM) is a rare disease that may cause unilateral vision loss in young adults after a flu-like illness. Occasionally, it is associated with hand–foot–mouth disease (HFMD) and is often underdiagnosed. Herein, we report a case with characteristics of UAIM associated with HFMD with acute enteroviral infection. On the basis of the clinical findings using multimodality diagnostic imaging, including fundus image, optical coherence tomography, fluorescence angiography, and serological test for pan-enterovirus RNA polymerase chain reaction, we detailed the clinical course and postulated the pathogenesis of UAIM with choroiditis associated with HFMD. This study could remind every doctor of the potential visual loss caused by UAIM in HFMD, and referring patients to the ophthalmologic survey is important to eliminate potential visual impairment.

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