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Exogenous cryptococcal endophthalmitis in an immunocompetent patient

 Department of Ophthalmology, Northwell Health Eye Institute, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, New York, USA

Correspondence Address:
Daniel Zhu,
Department of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health Center for Adult Ophthalmology, 600 Northern Blvd, Suite 214, Great Neck, New York 11021
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.TJO-D-22-00095

We describe a case of exogenous cryptococcal endophthalmitis without central nervous system (CNS) involvement or systemic infection in an immunocompetent patient. An 82-year-old male with hypertension, hyperlipidemia, type 2 diabetes mellitus, and primary open-angle glaucoma with a history of left eye trabeculectomy presented with 3 months of worsening left eye pain and redness. Vitreous cultures resulted as Cryptococcus, prompting treatment with intravitreal amphotericin and further investigation. Systemic workup was unrevealing for an endogenous source, CNS involvement, or immunocompromising conditions. He was treated with an aggressive regimen of systemic antifungals, leading to subjective improvements in clinical exam and in vision.

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