An understanding of the pathogenesis of glaucoma is one of the foundations in glaucoma management. A number of theories have been presented to explain glaucomatous neural degeneration. The vascular theory attempts to explain the causation of glaucoma on the basis of vasogenic factors and altered he-modynamics in the body; however, this theory remains controversial. There are proponents for and against the role played by vascular factors in the development of glaucomatous optic nerve degeneration. This review aims to analyze the various studies performed to provide evidence for and against the vascular theory of glaucoma. It also affirms the need to undertake further studies regarding the path-ogenesis of glaucoma and integrate them into our management strategies. The literature search for this systemic analysis was performed using search engines, such as PubMed, The Virtual Library of the Ministry of Health Malaysia, Google Scholar, and ClinicalKey.

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Primary vitreoretinal lymphoma (PVRL) was previously termed primary intraocular lymphoma. PVRL is a potentially fatal intraocular malignancy, and 65–90% of PVRL cases eventually involve the central nervous system (CNS). The incidence of PVRL has been rising in both immunocompromised and immuno-competent populations worldwide. PVRL frequently masquerades as chronic uveitis. Advanced auxiliary examinations, such as optical coherence tomography and fundus autofluorescence have been applied in the diagnosis of PVRL. Histology and immunohistochemistry in combination with molecular tests and interleukin-10 analysis have been demonstrated as reliable in diagnosing PVRL. Despite early initiation of treatment, mortality is high with PVRL associated with CNS involvement and relapses are common. The use of systemic chemotherapy has not been proven to prevent CNS involvement; however, local therapies including intravitreal injections of methotrexate and/or rituximab and low-dose radiotherapy to the eye, has shown to be extremely effective in controlling intraocular lymphoma with encouraging results.

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Background/Purpose: To assess the distribution of near point of convergence (NPC), near heterophoria, and near vergence among myopic school children in South Korea. Methods: One hundred and thirty-six elementary school children, aged 8–13 years, were each given a thorough eye examination including binocular vision testing, NPC using standard push-up technique, horizontal heterophoria measurement by Von Graefe, distance, and near negative and positive vergence with a phoropter and phoropter replacement card. Results: NPC break and recovery points were highest in the age 9 years group, but the mean values of NPC were within the normal range. Of 136 individuals, 52 presented with esophoria, 53 presented with 0 –6-Δ exophoria, and 31 presented with >7-Δ exophoria. In the younger age groups (8 years and 10 years) 0–6-Δ exophoria was prevalent, whereas in the older age groups (11 years, 12 years, and 13 years) esophoria was prevalent. Near positive fusional vergence (break and recovery point) presented with statistically significant correlations with the participants’ ages. Esophoria showed higher correlations with high myopia (8.00 ± 0.000) rather than with low myopia (3.36 ± 2.499) or medium myopia (3.42 ± 2.149). The mean value of 0–6Δ exophoria was highest in medium myopia (4.04 ± 1.517), and of >7-Δ exophoria was the highest in high myopia (12.66 ± 1.154). Conclusion: There were no statistically significant correlations between the school childrens’ ages and NPC, near horizontal heterophoria, and near fusional vergence, except near positive fusional vergence. Also, unlike many studies, myopic magnitude did not present a significant correlation with near phoria and fusional vergence.

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Treacher Collins syndrome is a congenital disorder with bilaterally symmetric anomalies of the structures developing from the first and second branchial arches. The ocular and orbital features are an obligatory component for the diagnosis. We presented a case of typical, complete syndrome and also reviewed the varied ophthalmological manifestations of the disease in the literature. Antimongoloid slanting of palpebral fissures and lower lid colobomas are constant features of the syndrome. However, varied ocular and lacrimal drainage anomalies are also associated. TCS is a syndrome with multiple ocular and orbital features, a knowledge of which will help in the diagnosis of incomplete forms of the syndrome.

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Background/Purpose: The evolution of present surgical techniques for reattaching a primary retinal detachment will be reviewed starting from 1929, and the present techniques analyzed in regard to their morbidity, reoperation, and long-term visual function. Methods: Literature of retinal detachment operations during the past 80 years is reviewed, of which the author has first-hand experience during the past 40 years. There had been a change from surgery of the entire detachment to a surgery limited to the retinal break and a change from extraocular to intraocular surgery. Results: The four major operations for repair of a primary retinal detachment in use at the beginning of the 21^st century, have still one thing in common for sustained reattachment: to find and close the break that caused the primary retinal detachment and that would cause a redetachment, if not sealed completely. This is independent of whether the surgery is limited to the break or extends over the entire detachment and the same is true whether the surgery is performed as an extraocular or intraocular procedure. Conclusion: To find and close sufficiently the break in a primary retinal detachment has accompanied the efforts of retinal detachment surgeons during the past 80 years. This is still the premise for sustained reattachment. However, today four postulates have to be fulfilled: (1) retinal reattachment with the first operation; (2) the procedure should have a minimum of morbidity; (3) the procedure should not harbor secondary complications jeopardizing regained visual acuity; and (4) the procedure should be performed on a small budget with local anesthesia.

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Ocular syphilis has varied manifestations in the eye. Peripheral ulcerative keratitis (PUK) is a crescent-shaped ulcer involving the peripheral cornea and associated with thinning. PUK is caused by both autoimmune and infectious diseases, such as rheumatoid arthritis, tuberculosis, and herpes. Here, we report a rare case of bilateral PUK caused by syphilis. A 55-year-old man presented with recurrent pain and redness in both eyes for 2 months. The cornea of both eyes had bilateral peripheral crescent-shaped ulcers suggestive of PUK. The patient was started on topical steroids elsewhere, but the lesion was not showing any signs of healing. A series of investigations were performed, with positive venereal disease research laboratory and fluorescent treponemal antibody absorption tests. The patient was then started on systemic penicillin, as well as topical steroids. The response to the treatment was good and the ulcer began to heal. PUK as the presenting feature of acquired syphilis is a rare scenario. Such infective causes should be managed with systemic antimicrobials for optimal outcomes.

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The Q-switched Nd:YAG laser can cause significant ocular injury, because it can emit an invisible and powerful load of energy in a short period of time. One of these injuries is macular hole formation. We report the case of a 21-year-old woman who presented with acute floaters in her left eye after exposure to a Q-switched Nd:YAG laser. Her initial best-corrected visual acuity (BCVA) in the left eye was 20/80. Examination demonstrated an acute vitreous hemorrhage, and spectral-domain optical coherence tomography (SD-OCT) confirmed a full-thickness macular hole (FTMH). Four months after her injury, her BCVA deteriorated to 20/400, and she underwent vitrectomy, internal limiting membrane peeling, and gas injection. Three weeks following the procedure, her FTMH was closed, however, her BCVA remained 20/150. At her last office visit, 19 months after the surgery, the examination was unchanged. There are few reports of vitrectomy to close an FTMH after Nd:YAG laser exposure, and the factors that contribute to visual recovery remain unclear. The aim of this case report is to emphasize the importance of early diagnosis and surgical repair, and to review the literature and surgical outcomes of cases of Nd:YAG laser-induced macular holes. Imaging with SD-OCT was essential in evaluating the visual outcome, as it was dependent on the degree of photoreceptor and retinal pigment epithelium injury.

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Tick bite on the lower eyelid is a rare condition. We reported a case of contact dermatitis on the lower eyelid related to the tick infestation. Ticks are vectors for disease transmission. Symptoms and treatments for tick-borne diseases were reviewed.

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This manuscript describes a case of successful reattachment of a macular-off retinal detachment following optical coherence tomography-guided internal drainage of retained subretinal fluid following a nondrain method. To date, there has not been any documented treatment option for this common phenomenon. This novel technique describes a method to remove such fluid and successfully appose the retina to the retinal pigment epithelial layer.

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Evidence-based medicine (EBM) is a tool and guide for performing effective medical treatment. Here, as an example, EBM was applied to determine which between trabeculectomy and Baerveldt implant surgery would be more effective in a patient with a history of open-angle glaucoma. First, the author asked answerable clinical questions. Second, evidence using general search engines, such as the Cochrane Library or MEDLINE database, was collected. It was found that the Tube Versus Trabeculectomy (TVT) Study was a landmark study in determining optimum glaucoma surgical procedure. Third, the study’s level of evidence was carefully examined. As the TVT Study was a prospective, randomized multicenter control study, its level of evidence was high. Fourth, the evidence to actual clinical decisions was applied, calculating the magnitude of the treatment effect using the results of the TVT Study. The event (surgical failure) rate in the control (trabeculectomy) and experimental (tube implant) groups (control event rate and experimental event rate, respectively) was obtained and the absolute risk reduction (ARR) was calculated by subtracting the experimental event rate from the control event rate. The inverse of ARR is the number needed to treat (NNT), which is the number of patients who must be treated to prevent a bad outcome. Using this method, it is possible to calculate the absolute risk (adverse event) increase (ARI) and the number needed to harm one more patient (NNH = 1/ARI). The balance of NNT and NNH is called the “likelihood of being helped and harmed.” The practice of EBM integrates clinical expertise of individuals with the best available external clinical evidence from systematic research.

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